Perseverative behavior in rats with methamphetamine-induced neurotoxicity
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چکیده
منابع مشابه
Role of microglia in methamphetamine-induced neurotoxicity.
Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury...
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Methamphetamine (METH) is a potent psychostimulant with neurotoxic properties. Heavy use increases the activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrites, microglia stimulation, and induces hyperthermia and anorectic effects. Most METH recreational users also consume cannabis. Preclinical studies have shown that natural (Δ9-tetrahydrocannabinol, Δ9-THC) and synthe...
متن کاملMethamphetamine-induced neurotoxicity alters locomotor activity, stereotypic behavior, and stimulated dopamine release in the rat.
The neurochemical evidence of methamphetamine (MA)-induced toxicity to dopaminergic nerve terminals is well documented; however, the functional consequences are not clearly defined. The present study was designed to investigate whether MA-induced dopamine depletions affect locomotor activity, stereotypic behavior, and/or extracellular dopamine concentrations in the neostriatum. Male rats were t...
متن کاملMDMA -induced neurotoxicity in rats
Ž . Ž . The role of nitric oxide NO in the long-term serotoninergic neurotoxicity induced by " 3,4-methylenedioxymethamphetamine Ž . v Ž . Ž y1. Ž . MDMA in rats was investigiated. Pretreatment with N -nitro-L-arginine L-NOARG 10 mg kg , a nitric oxide synthase NOS Ž . Ž y1. inhibitor, partially protected against long-term serotonin 5-HT depletion induced by MDMA 40 mg kg in frontal cortex and ...
متن کاملCyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity.
Methamphetamine causes persistent damage to dopamine nerve endings of the striatum. The mechanisms underlying its neurotoxicity are not fully understood, but considerable evidence points to oxidative stress as a probable mechanism. A recent microarray analysis of gene expression changes caused by methamphetamine revealed that cyclooxygenase-2 (COX-2) was induced along with its transcription fac...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2013
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2012.09.021